The common, the uncommon and the not so obvious…

Some triggers of anaphylaxis, such as food, are common around the world. However, some triggers are uncommon, like horse dander or even cold water.Other triggers may not be so clear or obvious.Below are just a few examples:

Exercise-induced anaphylaxis

Exercise-induced anaphylaxis is a form of physical allergy with symptoms that include a warm feeling spreading throughout the entire body, itching and redness of the skin. Vigorous forms of physical activity, such as jogging, are more commonly associated with anaphylaxis, although lower levels of exertion (e.g., yard work) are also capable of triggering attacks.

Exercise-induced anaphylaxis is often associated with medications or foods that have been taken or eaten prior to or after exercise. Someone with a history of exercise-induced anaphylaxis due to foods should avoid exercising for four to six hours after eating. Exercise-triggered anaphylaxis has a higher incidence in people genetically predisposed to developing allergic conditions.

Idiopathic anaphylaxis

When no triggers for anaphylaxis can be identified, a diagnosis of idiopathic anaphylaxis is made. If you or your child experiences anaphylaxis and the cause is unknown, your healthcare professional will analyze the events and conditions surrounding the allergic reaction so you can be careful to avoid possible triggers.

Like other forms of life-threatening allergic reactions, a case of exercise-induced or idiopathic anaphylaxis is treated with epinephrine. In case of exercise-induced or idiopathic anaphylaxis, administer EpiPen® (epinephrine injection, USP) or EpiPen Jr® (epinephrine injection, USP) Auto-Injector (or their authorized generics) immediately and seek emergency medical care.

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More Important Safety Information

Use EpiPen® (epinephrine injection, USP) 0.3 mg or EpiPen Jr® (epinephrine injection, USP) 0.15 mg Auto-Injectors right away when you have an allergic emergency (anaphylaxis). Get emergency medical help right away. You may need further medical attention. Only a healthcare professional should give additional doses of epinephrine if you need more than two injections for a single anaphylactic episode. EpiPen® or EpiPen Jr® should only be injected into the middle of your outer thigh (upper leg), through clothing if necessary. Do not inject into your veins, buttocks, fingers, toes, hands or feet. Hold the leg of young children firmly in place before and during injection to prevent injuries. In case of accidental injection, please seek immediate medical treatment.

Rarely, patients who have used EpiPen® or EpiPen Jr® may develop an infection at the injection site within a few days. Some of these infections can be serious. Call your healthcare professional right away if you have any of the following at an injection site: redness that does not go away, swelling, tenderness, or the area feels warm to the touch.

Tell your healthcare professional about all of your medical conditions, especially if you have asthma, a history of depression, thyroid problems, Parkinson’s disease, diabetes, high blood pressure or heart problems, have any other medical conditions, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Be sure to also tell your healthcare professional all the medicines you take, especially medicines for asthma. If you have certain medical conditions, or take certain medicines, your condition may get worse or you may have longer lasting side effects when you use EpiPen® or EpiPen Jr®.

Common side effects include fast, irregular or “pounding” heartbeat, sweating, nausea or vomiting, breathing problems, paleness, dizziness, weakness, shakiness, headache, feelings of over excitement, nervousness or anxiety. These side effects usually go away quickly if you lie down and rest. Tell your healthcare professional if you have any side effect that bothers you or that does not go away.

Indications

EpiPen® and EpiPen Jr®  Auto-Injectors are for the emergency treatment of life-threatening allergic reactions (anaphylaxis) caused by allergens, exercise, or unknown triggers; and for people who are at increased risk for these reactions. EpiPen® and EpiPen Jr® are intended for immediate administration as emergency supportive therapy only. Seek immediate emergency medical help right away.


Please see the full Prescribing Information and Patient Information.

For additional information please contact us at 800-796-9526.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

EpiPen® & EpiPen Jr® (epinephrine injection, USP) Auto-Injectors 0.3/0.15mg

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