Doctor, young girl, and adult woman in exam room

Antihistamine or epinephrine?

Antihistamines are commonly used for treating hives or other skin symptoms, but they do not treat the life‑threatening symptoms of anaphylaxis (Here are some of the symptoms to watch for). According to National Food Allergy Guidelines, epinephrine is the only recommended first‑line treatment for anaphylaxis. Epinephrine is the medication in EPIPEN® and EPIPEN JR® (epinephrine injection, USP) Auto-Injectors and their authorized generics.

Anaphylaxis is unpredictable.

In addition, the severity, progression, and duration of the symptoms of anaphylaxis are inconsistent and unpredictable. It is important to talk to your healthcare professional about your risks.

Vigilance is essential.

Because of this unpredictability, it's crucial for parents and caregivers of children living with potentially life-threatening, or severe, allergies—as well as adults with severe allergies—to be vigilant. Avoiding known allergens is the only way to help prevent anaphylaxis. Do everything possible to avoid your allergens.

- Make sure that family members, school personnel, babysitters or anyone else who may be responsible for the care of your child or children with severe allergies knows what allergens need to be avoided

- When cooking and preparing food take steps to avoid allergens

- Plan ahead when eating out or traveling - inform restaurants and airlines about any known allergens and ask about their food allergy policy

Talk to a healthcare professional about how to identify the signs and symptoms of a life-threatening allergic reaction (anaphylaxis).

Recognize the symptoms that might occur.

Anaphylaxis is a severe or potentially life‑threatening allergic emergency that occurs very quickly—even as fast as within a couple of minutes of exposure to an allergen.

What should you do?

If you, your child or someone you're caring for shows signs or symptoms of anaphylaxis, administer EPIPEN or EPIPEN JR  Auto‑Injector or their authorized generics immediately and seek emergency medical care.

Acting fast can make a difference.

In all cases of anaphylaxis, prompt assessment and treatment are critical. Epinephrine is the only first-line treatment for anaphylaxis. If you suspect you're having a severe allergic emergency (anaphylaxis), don't hesitate to use an epinephrine auto-injector and immediately seek emergency medical care.

What should I tell my doctor before using EPIPEN, EPIPEN JR or their authorized generics?

Before you use EPIPEN, EPIPEN JR or their authorized generics, tell your healthcare professional about all your medical conditions, but especially if you have heart problems or high blood pressure, diabetes, thyroid problems, asthma, a history of depression, or Parkinson’s disease; have any other medical conditions; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed. Especially tell your healthcare professional if you take certain asthma medicines.

Use your brand or generic EPIPEN Auto-Injector in the event of an anaphylactic emergency as prescribed by your healthcare professional, regardless of medical conditions or medication. People with certain medical conditions have a higher chance of having serious side effects from EPIPEN or its authorized generic.

Next: What Is Epinephrine?

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Antihistamines are not recommended for the life-threatening symptoms of anaphylaxis.

Learn why »

INDICATIONS (the following information applies to both Epipen and its Authorized Generic)

EPIPEN® and EPIPEN JR® Auto-Injectors are used to treat life-threatening, allergic emergencies in people who are at risk for or have a history of serious allergic emergencies. EPIPEN and EPIPEN JR are for immediate administration by you or your caregiver. They do not take the place of emergency medical care. You should get emergency help right away after using your EPIPEN of EPIPEN JR.

IMPORTANT SAFETY INFORMATION (the following information applies to both EPIPEN and its Authorized Generic)

EPIPEN® (epinephrine injection, USP) 0.3 mg and EPIPEN JR® (epinephrine injection, USP) 0.15 mg Auto-Injectors are used to treat allergic emergencies (anaphylaxis). Anaphylaxis can be life threatening and happen within minutes. If untreated, anaphylaxis can cause death. This allergic emergency can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise, or unknown causes.

Always carry 2 EPIPEN or 2 EPIPEN JR Auto-Injectors with you because sometimes a single dose of epinephrine may not be enough to treat a serious allergic reaction before seeking medical care.

When you have an allergic emergency (anaphylaxis), use EPIPEN or EPIPEN JR auto-injectors right away. Get emergency medical help right away even if you have used the EPIPEN or EPIPEN JR auto-injector. You can use a second EPIPEN or EPIPEN JR auto-injector if symptoms continue or if the first auto-injector is activated. If you need more than 2 doses for an allergic emergency, they must be given by a healthcare provider.

Before you use EPIPEN or EPIPEN JR auto-injectors, tell your healthcare provider about all your medical conditions if you have heart problems with high blood pressure, diabetes, thyroid problems, asthma, a history of depression, Parkinson’s disease, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Tell your healthcare provider about all of your known allergies. If you have certain medical conditions, or take certain medicines, your condition may get worse, or you may have longer lasting side effects when you use your EPIPEN or EPIPEN JR auto-injector.

Especially tell your healthcare provider if you take certain asthma medicines. EPIPEN and EPIPEN JR and other medicines may affect the way other medicines work. Other medicines my affect how EPIPEN and EPIPEN JR auto-injector works.

EPIPEN or EPIPEN JR auto-injector should be injected into the middle of your outer thigh (upper leg), through clothing if necessary. Do not inject into your veins, buttocks, fingers, toes, hands or feet. It is very important that you hold the EPIPEN or EPIPEN JR auto-injector down firmly on the middle of the outer thigh (upper leg) for at least 3 full seconds. If you do not hold it in place long enough, the EPIPEN or EPIPEN JR auto-injector might not have time to deliver the correct dose of medicine. If you accidentally inject EPIPEN or EPIPEN JR auto-injectors into any place other than the middle of your outer thigh, go to the nearest emergency room right away. If you inject a young child, hold their leg firmly in place before and during the 3 second injection to prevent injuries.

Rarely, patients who have used EPIPEN or EPIPEN JR auto-injectors may get infections at the injection site within a few days. Some of these infections can be serious. Call your healthcare professional right away if you have any of the following at an injection site: redness that does not go away, swelling, tenderness, or the area feels warm to the touch.

Common side effects include fast, irregular or “pounding” heartbeat, sweating, nausea or vomiting, breathing problems, paleness, dizziness, weakness, shakiness, headache, feelings of over excitement, nervousness or anxiety. These side effects may go away with rest. Tell your healthcare professional if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA- 1088.


 Please see the full Prescribing Information and Patient Information for EPIPEN.

Please see the full Prescribing Information and Patient Information for the Authorized Generic for EPIPEN.

For additional information please contact us at 800-796-9526.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

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INDICATIONS (the following information applies to both EPIPEN and its Authorized Generic)

EPIPEN® and EPIPEN JR® Auto-Injectors are used to treat life-threatening, allergic emergencies in people who are at risk for or have a history of serious allergic emergencies. EPIPEN and EPIPEN JR are for immediate administration by you or your caregiver. They do not take the place of emergency medical care. You should get emergency help right away after using your EPIPEN of EPIPEN JR.

INDICATIONS (the following information applies to both EPIPEN and its Authorized Generic)

EPIPEN® and EPIPEN JR® Auto-Injectors are used to treat life-threatening, allergic emergencies in people who are at risk for or have a history of serious allergic emergencies. EPIPEN and EPIPEN JR are for immediate administration by you or your caregiver. They do not take the place of emergency medical care. You should get emergency help right away after using your EPIPEN of EPIPEN JR.

IMPORTANT SAFETY INFORMATION (the following information applies to both EPIPEN and its Authorized Generic)

EPIPEN® (epinephrine injection, USP) 0.3 mg and EPIPEN JR® (epinephrine injection, USP) 0.15 mg Auto-Injectors are used to treat allergic emergencies (anaphylaxis). Anaphylaxis can be life threatening and happen within minutes. If untreated, anaphylaxis can cause death. This allergic emergency can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise, or unknown causes.

Always carry 2 EPIPEN or 2 EPIPEN JR Auto-Injectors with you because sometimes a single dose of epinephrine may not be enough to treat a serious allergic reaction before seeking medical care.

When you have an allergic emergency (anaphylaxis), use EPIPEN or EPIPEN JR auto-injectors right away. Get emergency medical help right away even if you have used the EPIPEN or EPIPEN JR auto-injector. You can use a second EPIPEN or EPIPEN JR auto-injector if symptoms continue or if the first auto-injector is activated. If you need more than 2 doses for an allergic emergency, they must be given by a healthcare provider.

Before you use EPIPEN or EPIPEN JR auto-injectors, tell your healthcare provider about all your medical conditions if you have heart problems with high blood pressure, diabetes, thyroid problems, asthma, a history of depression, Parkinson’s disease, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Tell your healthcare provider about all of your known allergies. If you have certain medical conditions, or take certain medicines, your condition may get worse, or you may have longer lasting side effects when you use your EPIPEN or EPIPEN JR auto-injector.

Especially tell your healthcare provider if you take certain asthma medicines. EPIPEN and EPIPEN JR and other medicines may affect the way other medicines work. Other medicines my affect how EPIPEN and EPIPEN JR auto-injector works.

EPIPEN or EPIPEN JR auto-injector should be injected into the middle of your outer thigh (upper leg), through clothing if necessary. Do not inject into your veins, buttocks, fingers, toes, hands or feet. It is very important that you hold the EPIPEN or EPIPEN JR auto-injector down firmly on the middle of the outer thigh (upper leg) for at least 3 full seconds. If you do not hold it in place long enough, the EPIPEN or EPIPEN JR auto-injector might not have time to deliver the correct dose of medicine. If you accidentally inject EPIPEN or EPIPEN JR auto-injectors into any place other than the middle of your outer thigh, go to the nearest emergency room right away. If you inject a young child, hold their leg firmly in place before and during the 3 second injection to prevent injuries.

Rarely, patients who have used EPIPEN or EPIPEN JR auto-injectors may get infections at the injection site within a few days. Some of these infections can be serious. Call your healthcare professional right away if you have any of the following at an injection site: redness that does not go away, swelling, tenderness, or the area feels warm to the touch.

Common side effects include fast, irregular or “pounding” heartbeat, sweating, nausea or vomiting, breathing problems, paleness, dizziness, weakness, shakiness, headache, feelings of over excitement, nervousness or anxiety. These side effects may go away with rest. Tell your healthcare professional if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA- 1088.


 Please see the full Prescribing Information and Patient Information for EPIPEN.

Please see the full Prescribing Information and Patient Information for the Authorized Generic for EPIPEN.

For additional information please contact us at 800-796-9526.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

  • About EPIPEN and the Authorized Generic for EPIPEN
  • What Is Anaphylaxis?
  • Have a Plan
  • Access to EPIPEN and the Authorized Generic to EPIPEN
  • About EPIPEN and the Authorized Generic for EPIPEN
  • What Is Anaphylaxis?
  • Have a Plan
  • Access to EPIPEN and the Authorized Generic to EPIPEN
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