
What’s inside your EPIPEN® (epinephrine injection, USP) Auto-Injector and its authorized generic?
You’ve probably heard of epinephrine under it’s non-technical name—adrenaline. When you ride a roller coaster or give a presentation, you may feel your heart beat a little faster, your breath intake increase and a sudden burst of energy. That’s adrenaline at work, a substance your body naturally releases under stress. And the medicine inside EPIPEN and EPIPEN JR® (epinephrine injection, USP) Auto-Injectors and the authorized generics happens to be a synthetic version of adrenaline—epinephrine.
Epinephrine vs. Adrenaline? What’s the difference?
Nothing. Epinephrine and adrenaline are the same thing. However, the preferred name of the substance inside your EPIPEN Auto-Injector or its authorized generic varies by where you live. In Europe, the term “adrenaline” is more common, while in the United States the term “epinephrine” is used.
So, how does epinephrine work during a life-threatening allergic reaction?
It constricts blood vessels to increase blood pressure, relaxes smooth muscles in the lungs to reduce wheezing and improve breathing, stimulates the heart (increases heart rate) and works to reduce hives and swelling that may occur around the face and lips.
When to treat with epinephrine and antihistamines.
According to national food allergy guidelines, epinephrine is the only recommended first-line treatment for anaphylaxis. Not antihistamines, which do not relieve shortness of breath, wheezing, gastrointestinal symptoms or shock. Therefore, antihistamines should not be a substitute for epinephrine.
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Antihistamines are not recommended for the life-threatening symptoms of anaphylaxis.
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IMPORTANT SAFETY INFORMATION (the following information applies to both EPIPEN and its Authorized Generic)
Use EPIPEN (epinephrine injection, USP) 0.3 mg or EPIPEN JR (epinephrine injection, USP) 0.15 mg Auto-Injectors right away when you have an allergic emergency (anaphylaxis). Get emergency medical help right away. You may need further medical attention. Only a healthcare professional should give additional doses of epinephrine if you need more than two injections for a single anaphylactic episode. EPIPEN or EPIPEN JR should only be injected into the middle of your outer thigh (upper leg), through clothing if necessary. Do not inject into your veins, buttocks, fingers, toes, hands or feet. Hold the leg of young children firmly in place before and during injection to prevent injuries. In case of accidental injection, please seek immediate medical treatment.

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