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What’s inside your EPIPEN® (epinephrine injection, USP) Auto-Injector and its authorized generic?

You’ve probably heard of epinephrine under it’s non-technical name—adrenaline. When you ride a roller coaster or give a presentation, you may feel your heart beat a little faster, your breath intake increase and a sudden burst of energy. That’s adrenaline at work, a substance your body naturally releases under stress. And the medicine inside EPIPEN and EPIPEN JR® (epinephrine injection, USP) Auto-Injectors and the authorized generics happens to be a synthetic version of adrenaline—epinephrine.

Epinephrine vs. Adrenaline? What’s the difference?

Nothing. Epinephrine and adrenaline are the same thing. However, the preferred name of the substance inside your EPIPEN Auto-Injector or its authorized generic varies by where you live. In Europe, the term “adrenaline” is more common, while in the United States the term “epinephrine” is used.

So, how does epinephrine work during a life-threatening allergic reaction?

It constricts blood vessels to increase blood pressure, relaxes smooth muscles in the lungs to reduce wheezing and improve breathing, stimulates the heart (increases heart rate) and works to reduce hives and swelling that may occur around the face and lips.

When to treat with epinephrine and antihistamines.

According to national food allergy guidelines, epinephrine is the only recommended first-line treatment for anaphylaxis. Not antihistamines, which do not relieve shortness of breath, wheezing, gastrointestinal symptoms or shock. Therefore, antihistamines should not be a substitute for epinephrine.

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Antihistamines are not recommended for the life-threatening symptoms of anaphylaxis.

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IMPORTANT SAFETY INFORMATION (the following information applies to both EPIPEN and its Authorized Generic)

Use EPIPEN (epinephrine injection, USP) 0.3 mg or EPIPEN JR (epinephrine injection, USP) 0.15 mg Auto-Injectors right away when you have an allergic emergency (anaphylaxis). Get emergency medical help right away. You may need further medical attention. Only a healthcare professional should give additional doses of epinephrine if you need more than two injections for a single anaphylactic episode. EPIPEN or EPIPEN JR should only be injected into the middle of your outer thigh (upper leg), through clothing if necessary. Do not inject into your veins, buttocks, fingers, toes, hands or feet. Hold the leg of young children firmly in place before and during injection to prevent injuries. In case of accidental injection, please seek immediate medical treatment.

Rarely, patients who have used EPIPEN or EPIPEN JR may develop an infection at the injection site within a few days. Some of these infections can be serious. Call your healthcare professional right away if you have any of the following at an injection site: redness that does not go away, swelling, tenderness, or the area feels warm to the touch.

Tell your healthcare professional about all of your medical conditions, especially if you have asthma, a history of depression, thyroid problems, Parkinson’s disease, diabetes, high blood pressure or heart problems, have any other medical conditions, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Be sure to also tell your healthcare professional all the medicines you take, especially medicines for asthma. If you have certain medical conditions, or take certain medicines, your condition may get worse or you may have longer lasting side effects when you use EPIPEN or EPIPEN JR.

Common side effects include fast, irregular or “pounding” heartbeat, sweating, nausea or vomiting, breathing problems, paleness, dizziness, weakness, shakiness, headache, feelings of over excitement, nervousness or anxiety. These side effects usually go away quickly if you lie down and rest. Tell your healthcare professional if you have any side effect that bothers you or that does not go away.

Indications (the following information applies to both EPIPEN and its Authorized Generic)

EPIPEN and EPIPEN JR  Auto-Injectors are for the emergency treatment of life-threatening allergic reactions (anaphylaxis) caused by allergens, exercise, or unknown triggers; and for people who are at increased risk for these reactions. EPIPEN and EPIPEN JR are intended for immediate administration as emergency supportive therapy only. Seek immediate emergency medical help right away.


 Please see the full Prescribing Information and Patient Information for EPIPEN.

Please see the full Prescribing Information and Patient Information for the Authorized Generic for EPIPEN.

For additional information please contact us at 800-796-9526.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

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IMPORTANT SAFETY INFORMATION (the following information applies to both EPIPEN and its Authorized Generic)

Use EPIPEN (epinephrine injection, USP) 0.3 mg or EPIPEN JR (epinephrine injection, USP) 0.15 mg Auto-Injectors right away when you have an allergic emergency (anaphylaxis). Get emergency medical help right away. You may need further medical attention. Only a healthcare professional should give additional doses of epinephrine if you need more than two injections for a single anaphylactic episode. EPIPEN or EPIPEN JR should only be injected into the middle of your outer thigh (upper leg), through clothing if necessary. Do not inject into your veins, buttocks, fingers, toes, hands or feet. Hold the leg of young children firmly in place before and during injection to prevent injuries. In case of accidental injection, please seek immediate medical treatment.

IMPORTANT SAFETY INFORMATION (the following information applies to both EPIPEN and its Authorized Generic)

Use EPIPEN (epinephrine injection, USP) 0.3 mg or EPIPEN JR (epinephrine injection, USP) 0.15 mg Auto-Injectors right away when you have an allergic emergency (anaphylaxis). Get emergency medical help right away. You may need further medical attention. Only a healthcare professional should give additional doses of epinephrine if you need more than two injections for a single anaphylactic episode. EPIPEN or EPIPEN JR should only be injected into the middle of your outer thigh (upper leg), through clothing if necessary. Do not inject into your veins, buttocks, fingers, toes, hands or feet. Hold the leg of young children firmly in place before and during injection to prevent injuries. In case of accidental injection, please seek immediate medical treatment.

Rarely, patients who have used EPIPEN or EPIPEN JR may develop an infection at the injection site within a few days. Some of these infections can be serious. Call your healthcare professional right away if you have any of the following at an injection site: redness that does not go away, swelling, tenderness, or the area feels warm to the touch.

Tell your healthcare professional about all of your medical conditions, especially if you have asthma, a history of depression, thyroid problems, Parkinson’s disease, diabetes, high blood pressure or heart problems, have any other medical conditions, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Be sure to also tell your healthcare professional all the medicines you take, especially medicines for asthma. If you have certain medical conditions, or take certain medicines, your condition may get worse or you may have longer lasting side effects when you use EPIPEN or EPIPEN JR.

Common side effects include fast, irregular or “pounding” heartbeat, sweating, nausea or vomiting, breathing problems, paleness, dizziness, weakness, shakiness, headache, feelings of over excitement, nervousness or anxiety. These side effects usually go away quickly if you lie down and rest. Tell your healthcare professional if you have any side effect that bothers you or that does not go away.

Indications (the following information applies to both Epipen and its Authorized Generic)

EPIPEN and EPIPEN JR  Auto-Injectors are for the emergency treatment of life-threatening allergic reactions (anaphylaxis) caused by allergens, exercise, or unknown triggers; and for people who are at increased risk for these reactions. EPIPEN and EPIPEN JR are intended for immediate administration as emergency supportive therapy only. Seek immediate emergency medical help right away.


 Please see the full Prescribing Information and Patient Information for EPIPEN.

Please see the full Prescribing Information and Patient Information for the Authorized Generic for EPIPEN.

For additional information please contact us at 800-796-9526.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

  • About EPIPEN and the Authorized Generic for EPIPEN
  • What Is Anaphylaxis?
  • Have a Plan
  • Access to EPIPEN and the Authorized Generic to EPIPEN
  • About EPIPEN and the Authorized Generic for EPIPEN
  • What Is Anaphylaxis?
  • Have a Plan
  • Access to EPIPEN and the Authorized Generic to EPIPEN
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