
It's an extreme response to an allergen.
A life-threatening allergic reaction (anaphylaxis) is a severe reaction to a specific allergen, or allergic trigger. Common triggers can include but are not limited to food, biting or stinging insects, medications and latex. Exercise-induced anaphylaxis is also possible, and sometimes anaphylaxis has no apparent cause at all (this is known as idiopathic anaphylaxis).
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What happens inside the body when anaphylaxis occurs?
The first step occurs when an allergen enters the body and causes antibodies (special proteins made by the body’s immune system) to form. These antibodies sensitize certain immune cells (called mast cells and basophils) to react the next time they encounter that specific allergen. When the allergen and these sensitized immune cells meet again, the antibodies cause the release of certain molecules (including histamine) that produce the immediate symptoms of anaphylaxis.
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Antihistamines are not recommended for the life-threatening symptoms of anaphylaxis.
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IMPORTANT SAFETY INFORMATION (the following information applies to both EPIPEN and its Authorized Generic)
Use EPIPEN (epinephrine injection, USP) 0.3 mg or EPIPEN JR (epinephrine injection, USP) 0.15 mg Auto-Injectors right away when you have an allergic emergency (anaphylaxis). Get emergency medical help right away. You may need further medical attention. Only a healthcare professional should give additional doses of epinephrine if you need more than two injections for a single anaphylactic episode. EPIPEN or EPIPEN JR should only be injected into the middle of your outer thigh (upper leg), through clothing if necessary. Do not inject into your veins, buttocks, fingers, toes, hands or feet. Hold the leg of young children firmly in place before and during injection to prevent injuries. In case of accidental injection, please seek immediate medical treatment.

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