Safety considerations

EpiPen® (epinephrine injection, USP) 0.3 mg and EpiPen Jr® (epinephrine injection, USP) 0.15 mg Auto-Injectors should only be injected into the anterolateral aspect of the thigh. Do not inject intravenously, into buttock, or into digits, hands, or feet. Instruct caregivers to hold the leg of young children firmly in place and limit movement prior to and during injection to minimize risk of injection-related injury. 

Epinephrine should be used with caution in patients with heart disease, and in patients who are on drugs that may sensitize the heart to arrhythmias, because it may precipitate or aggravate angina pectoris and produce ventricular arrhythmias. Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or taking cardiac glycosides, diuretics, or anti-arrhythmics. 

Patients with certain medical conditions or who take certain medications for allergies, depression, thyroid disorders, diabetes, and hypertension, may be at greater risk for adverse reactions. Common adverse reactions to epinephrine include anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea and vomiting, headache, and/or respiratory difficulties.  


There are no absolute contraindications to epinephrine administration for an anaphylactic reaction.1,2

Storing the EpiPen® Auto-Injector

EpiPen® and EpiPen Jr® (epinephrine injection, USP) Auto-Injectors should be stored in the carrier tube provided at a temperature of 25ºC (77ºF); however, temperature excursions between 15ºC and 30ºC (59ºF to 86ºF) are permitted.1 EpiPen® and EpiPen Jr® Auto-Injectors should not be stored in refrigerators or in a vehicle’s glove box.1 EpiPen® Auto-Injectors should not be exposed to extreme heat or cold and should be protected from light.2

Disposing of a used EpiPen® Auto-Injector

It is important to communicate to your patients that used EpiPen® Auto-Injectors must be disposed of properly.3 They should be taken to a healthcare professional’s office or to a hospital for proper disposal.1 Also, remind your patients to obtain a replacement for any used EpiPen® Auto-Injector.1

How chemically stable is epinephrine?

Epinephrine solution deteriorates rapidly on exposure to air or light, turning pink from oxidation to adrenochrome and brown from the formation of melanin. Patients should be instructed to visually inspect the epinephrine solution periodically for particulate matter and discoloration. Patients should also be advised to replace their EpiPen® or EpiPen Jr® Auto-Injector if the epinephrine solution contains particulate matter or develops a pinkish or brown color, because these changes indicate that the effectiveness of the drug product may have decreased or been affected. It is important to follow recommended storage conditions.1

How should EpiPen® Auto-Injector be carried?

Until EpiPen® Auto-Injector needs to be used, it should be carried in the carrier tube with the blue safety release cap on.1 A complimentary carrying case is available to patients on epipen.com.

My patient accidentally injected himself/herself with EpiPen® Auto-Injector. What should I do?

Because epinephrine is a strong vasoconstrictor, accidental injection into fingers, hands or feet may result in decrease or loss of blood flow to these areas.1 The patient should be advised to go immediately to the nearest emergency department and to inform the healthcare professional in the emergency department of the location of the accidental injection.1 Patients are also instructed to ask for a refill prescription.1

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