History doesn’t always prepare us for the future.
Anaphylaxis is unpredictable. The severity of future anaphylactic reactions cannot be accurately predicted based on the level of sIgE, the size of the skin prick test wheal or the severity of past reaction.1,2 In addition:
- Up to 20% of children will not have cutaneous symptoms during an anaphylactic reaction3
- Involvement of body organ systems in anaphylaxis varies among patients, and even in the same patient from one allergic reaction to another4-6
EPIPEN and EPIPEN JR® (epinephrine injection, USP), and their authorized generic auto-injectors
Viatris' branded and authorized generic auto-injectors are used for the emergency treatment of the signs and symptoms of anaphylaxis, including pruritus, urticaria, angioedema, flushing, syncope, tachycardia and dyspnea due to laryngeal spasm and/or a decrease in blood pressure. Anaphylaxis can be caused by triggers such as food, biting or stinging insects, medicines, latex or even radiocontrast media and exercise.5-9
EPIPEN Auto-Injector has been the most prescribed brand of self-injectable epinephrine for more than 30 years.10
In that time, nearly 80 million EPIPEN Auto-Injectors have been dispensed.10
Watch a step-by-step video for patients on how to use the EPIPEN Auto-Injector and its authorized generic.
Make most of EPIPEN by watching our step-by-step video showing how to use the device properly.
How to Use an EPIPEN (epinephrine injection, USP) Auto-Injector Video
A life-threatening allergic reaction, anaphylaxis—
—is unpredictable. It could be mild one minute, then suddenly—
It’s scary. Like, you can’t even breathe scary…
—or your skin gets all itchy and breaks out into hives scary—
—or your throat starts to tickle and close scary... It’s different for everybody.
Every reaction is different. A mild reaction one time can be life-threatening the next. So, it’s important to know your body and know when it starts to feel funny. It could be the warning signs of anaphylaxis.
So, it’s also important to know how to use one of these.
…An EPIPEN Auto-Injector.
EPIPEN and EPIPEN JR are for the emergency treatment of life-threatening allergic reactions…
…and for people who are at an increased risk for these reactions.
EPIPEN and EPIPEN JR should only be used to help someone during an emergency.
Ready to show them how it’s done?
EPIPEN JR, the one with the green label, is for kids—
And EPIPEN, with the yellow label—for bigger people, like me.
Whether you need to use EPIPEN on yourself or give it to someone else, you can just follow these simple steps.
So, first thing’s first, you take it out of the tube
Just flip open the yellow cap…
MOM: —or the green cap—
Slide it out… and hold it like this—
Blue to the sky…
Orange to the thigh.
Then, you take off the blue cap…
Blue safety release.
Never put your hands near the orange tip, because that’s where the needle comes out…
The needle is designed to go through clothing, including jeans, because it must be injected into the outer thigh, for quick absorption. And if you’re helping a young child...
: Like me!
..hold their leg firmly in place. Once it is…
You just do this—
It clicks, so you know it worked. Then you hold it there for 3 seconds…
Then, remove EPIPEN…
You’ll still see some liquid in there. Don’t worry. Your EPIPEN JR Auto-Injector gave you the right dose. And it has a special feature—the NEVER-SEE-NEEDLE.
Yeah. So, the needle is totally covered up.
So you should never see the needle.
Then, rub the spot for 10 seconds while you or someone else gets emergency medical help right away.
Call the ambulance.
Or have someone take you to the Emergency Room.
Just make sure to do it immediately.
And you should always carry two EPIPEN
Auto-Injectors, wherever you go. They even come clipped together.
Because some people might need the second dose.
Remember, epinephrine is the only first-line treatment for anaphylaxis. Not antihistamines.
So, just trust yourself and do it. Don’t hesitate. Especially, if you know the symptoms of a life-threatening allergic reaction and have practiced with the grey Trainer that comes in the box.
…Because this is what’s important to people like me…
A design familiar to millions10
Viatris' authorized generic is identical to EPIPEN in design and function—only the name on the label is different
Access to two for your patients
EPIPEN, EPIPEN JR and their authorized generic auto-injectors are available in cartons of two.8,9 Up to 20% of patients need additional doses due to a biphasic reaction or protracted symptoms.1,6 According to national food allergy guidelines, it is recommended to have access to two epinephrine auto-injectors, which provides two sequential doses if needed during an anaphylactic reaction.1 Each carton also includes a Trainer, which may be valuable in promoting patient familiarity with the administration of EPIPEN Auto-Injector or its authorized generic.8,9
- Boyce JA, Assa’ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126(6 Suppl):S1-S58.
- Simons FE. Anaphylaxis: recent advances in assessment and treatment. J Allergy Clin Immunol. 2009;124(4):625-636.
- Järvinen KM, Celestin J. Anaphylaxis avoidance and management: educating patients and their caregivers. J Asthma Allergy. 2014;7:95-104.
- Dinakar C. Anaphylaxis in children: current understanding and key issues in diagnosis and treatment. Curr Allergy Asthma Rep. 2012;12(6):641-649.
- Lieberman P, Nicklas RA, Randolph C, et al. Anaphylaxis—a practice parameter update 2015. Ann Allergy Asthma Immunol. 2015;115(5):341-384.
- Simons FE. Anaphylaxis. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S161-S181.
- Volcheck GW. Clinical Allergy: Diagnosis and Management. Rochester, MN: Mayo Foundation for Medical Education and Research; 2009.
- EPIPEN [prescribing & patient information]. Morgantown, WV: Mylan Specialty L.P.; 11/2021.
- Epinephrine Injection, USP [prescribing & patient information]. Morgantown, WV: Mylan Specialty L.P.; 12/2020.
- Data on file: IMS Report (1987-September 2020). (Data includes prescriptions for the authorized generic of EPIPEN and EPIPEN JR.)
- Ram FSF, Hoare K, Arroll B, Hoare S. Epinephrine self-administration in anaphylactic emergencies: comparison of commonly available autoinjectors. J Asthma Allergy Educ. 2012;3(4):178-181.