What to expect from patients

In the event of anaphylaxis, it is recommended that patients inject EpiPen® (epinephrine injection, USP) or EpiPen Jr® (epinephrine injection, USP) Auto-Injector immediately and seek emergency medical attention.1-3 The Patient Information for EpiPen® Auto-Injector recommends that patients take the used EpiPen® Auto-Injector with them to the emergency room for inspection and disposal.4 Patients are then instructed to ask for a new prescription and EpiPen® Auto-Injector replacement, if needed.1

The continuum of anaphylaxis

The progression of anaphylaxis is not absolute.6 The signs and symptoms can arise within minutes of exposure to an allergen, but can also develop 30 minutes or more after exposure.2,6 Moreover, symptoms that do not initially appear to be life-threatening may progress rapidly unless proper treatment is given.2,6 In some cases, a second allergic reaction occurs 1 to 72 hours (usually within 8 hours) after initial recovery despite no further exposure to the trigger.2,7,8 This is known as a biphasic reaction, and it can occur in up to 20% of all anaphylactic reactions.2,7 Because biphasic reactions are unpredictable (even while administering immunotherapy), it is important that observation periods in the office be individualized for each patient.3,6

Guidelines from the National Institutes of Health and National Institute of Allergy and Infectious Diseases (NIH-NIAID) recommend that patients who were seen in the emergency department for anaphylaxis be discharged with a prescription for epinephrine so that they have access to two doses of epinephrine at all times.4,5

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