When Should Epinephrine Be Administered?

When Should Epinephrine Be Administered?

The immediate administration of epinephrine is critical for all patients meeting any of the 3 criteria outlined in the “Criteria for Diagnosing Anaphylaxis” section.4,7 Any delay in treatment increases the risk of a fatal anaphylactic reaction or a biphasic reaction in these patients.4 Some patients not meeting these criteria may still need an immediate injection.7 For example, patients who have had a previous near-fatal anaphylactic reaction and who are exhibiting signs of even a mild reaction after exposure to a known allergen should receive emergency treatment.7 There are no absolute contraindications to epinephrine administration for an anaphylactic reaction.6,8 It is important to administer epinephrine immediately.1,2,4


EpiPen® (epinephrine) 0.3 mg and EpiPen Jr® (epinephrine) 0.15 mg Auto-Injectors are indicated in the emergency treatment of type 1 allergic reactions, including anaphylaxis, to allergens, idiopathic and exercise-induced anaphylaxis, and in patients with a history or increased risk of anaphylactic reactions. Selection of the appropriate dosage strength is determined according to body weight.

Important Safety Information

EpiPen Auto-Injectors should only be injected into the anterolateral aspect of the thigh. DO NOT INJECT INTO BUTTOCK, OR INTRAVENOUSLY.

Epinephrine should be used with caution in patients with certain heart diseases, and in patients who are on drugs that may sensitize the heart to arrhythmias, because it may precipitate or aggravate angina pectoris and produce ventricular arrhythmias. Arrhythmias, including fatal ventricular fibrillation, have been reported in patients with underlying cardiac disease or taking cardiac glycosides or diuretics. Patients with certain medical conditions or who take certain medications for allergies, depression, thyroid disorders, diabetes, and hypertension, may be at greater risk for adverse reactions. Other adverse reactions include transient moderate anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea and vomiting, headache, and/or respiratory difficulties.

EpiPen and EpiPen Jr Auto-Injectors are intended for immediate self-administration as emergency supportive therapy only and are not intended as a substitute for immediate medical or hospital care.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For additional information please contact us at 800-395-3376.