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Scroll down or Click Here forEpinephrine should be immediately administered to a patient who fulfills any of the 3 criteria outlined in the ‘criteria for diagnosing anaphylaxis’ section.5 Prompt injection is important, as delayed injection of epinephrine is associated with fatal anaphylactic reactions.2,3,6 There will be patients, however, who present with symptoms not meeting the criteria for an anaphylaxis diagnosis in whom it would be appropriate to initiate epinephrine therapy.5 Such patients include those who have had prior near-fatal anaphylactic reactions to peanut, for example, and within minutes of re-exposure experience urticaria and generalized flushing.5,7 There are no absolute contraindications to epinephrine administration for an anaphylactic reaction. It is important to administer epinephrine immediately.6