How to Use EpiPen Auto-Injector

How to Use EpiPen Auto-Injector

The first step in managing life-threatening allergies is to always avoid your allergens. But that’s not always possible. That’s why it’s important to always carry an EpiPen Auto-Injector just in case a reaction becomes life-threatening.

Preparation is key. Don’t wait until an emergency to learn how to use your EpiPen Auto-Injector. Make sure you and everyone in your family who may need to use the EpiPen Auto-Injector are well versed in using it. Start with this video demonstration.


EpiPen Auto-Injector Step-by-Step Instructions (PDF) click here to download

This PDF includes 3-step, easy-to-follow instructions for using your EpiPen Auto-injector, as well as a fact sheet for the EpiPen training device that comes with your EpiPen 2-Pak®.

Patient Information (PDF) click here to download

Download this important safety information about EpiPen. If you have any questions about EpiPen, be sure to discuss them with your health care provider.

How to Use EpiPen Auto-Injector Step-by-Step instructions

  1. Prepare the EpiPen or EpiPen Jr Auto-Injector for Injection
    • Remove the auto-injector from the clear carrier tube. Flip open the yellow cap of your EpiPen or the green cap of your EpiPen Jr Auto-Injector carrier tube. Tip and slide the auto-injector out of the carrier tube.
    • Grasp the auto-injector in your fist with the orange tip pointing downward.
    • With your other hand, remove the blue safety release by pulling straight up without bending or twisting it.
      Note: The needle comes out of the orange tip.
    • Never put your thumb, fingers or hand over the orange tip.
  2. Administer the EpiPen or EpiPen Jr Auto-Injector

    Hold the auto-injector with orange tip near the outer thigh. Swing and firmly push the orange tip against the outer thigh until it “clicks”. Keep the auto-injector firmly pushed against the thigh at a 90° angle (perpendicular) to the thigh. Hold firmly against the thigh for approximately 10 seconds to deliver the drug. The injection is now complete.

  3. Finalize the Injection Process

    Remove the auto-injector from the thigh. The orange tip will extend to cover the needle. Massage the injection area for 10 seconds. Get emergency medical help right away. You may need further medical attention. You may need a second EpiPen or EpiPen Jr Auto-Injector should symptoms persist or recur.
    Note: Take your used auto-injector with you when you go to see the health care provider.

    • Tell the health care provider that you have received an injection of epinephrine. Show the health care provider where you received the injection.
    • Give your used EpiPen or EpiPen Jr Auto-Injector to a health care provider for inspection and proper disposal.
    • Ask for a refill, if needed.
    • The used auto-injector with extended needle cover will not fit in the carrier tube.
    • Most of the liquid medicine stays in the auto-injector and cannot be reused. You have received the correct dose of the medicine if the orange needle tip is extended and the window is blocked.
    • Your EpiPen or EpiPen Jr Auto-Injector may come packaged with an EpiPen Auto-Injector Trainer and separate Trainer Instructions for Use. The EpiPen Trainer has a grey color. The grey EpiPen Trainer contains no medicine and no needle. Practice with your EpiPen Trainer, but always carry your real EpiPen or EpiPen Jr Auto-Injector in case of an allergic emergency.
    • Do not attempt to take the EpiPen or EpiPen Jr Auto-Injector apart.

Important Safety Information

EpiPen® (epinephrine) Auto-Injectors contain a single dose of epinephrine, which you inject into your outer thigh. DO NOT INJECT INTO YOUR VEIN, BUTTOCK, FINGERS, TOES, HANDS OR FEET. In case of accidental injection, please seek immediate medical treatment. Epinephrine should be used with caution if you have heart disease or are taking certain medicines that can cause heart-related (cardiac) symptoms.

Tell your doctor if you have certain medical conditions such as asthma, depression, thyroid disease, Parkinson’s disease, diabetes, high blood pressure and heart disease, have any other medical conditions, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Be sure to also tell your doctor all the medicines you take, especially medicines for asthma. If you have certain medical conditions, or take certain medicines, your condition may get worse or you may have longer lasting side effects when you take the EpiPen or EpiPen Jr Auto Injector.

The most common side effects may include increase in heart rate, stronger or irregular heartbeat, sweating, nausea and vomiting, difficulty breathing, paleness, dizziness, weakness or shakiness, headache, apprehension, nervousness or anxiety. These side effects usually go away quickly, especially if you rest.

Talk to your health care professional to see if EpiPen or EpiPen Jr Auto-Injector is right for you.


EpiPen® (epinephrine) 0.3 mg and EpiPen Jr® (epinephrine) 0.15 mg Auto-Injectors are for the emergency treatment of life-threatening allergic reactions (anaphylaxis) caused by allergens, exercise, or unknown triggers; and for people who are at increased risk for these reactions. EpiPen and EpiPen Jr are intended for immediate self administration as emergency supportive therapy only. Seek immediate emergency medical treatment after use.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

For additional information please contact us at 800-395-3376.